Preventing the Accumulation of mRNA-Loaded Lipid Nanoparticles in the Liver ～Toward Safer Nanomedicine with Lower Dosages～
Summary
- Solving the problem of mRNA-loaded lipid nanoparticles accumulating in the liver and causing unintended expression of pharmacologically active proteins
- By coating the walls of intrahepatic capillaries (liver sinusoidal walls), the accumulation of lipid nanoparticles in the liver is prevented (demonstrated in animal studies)
- Improved efficacy and safety in infectious prevention vaccines, cancer treatment vaccines, and cytokine therapies
- Substances with established clinical safety profiles are used as coating agents (enabling rapid clinical trials)
- Published online in ACS Nano: http://doi.org/10.1021/acsnano.6c08403
