Type Of Media：医薬業界
Publication/Magazine/Media：医薬通信社
Development of mRNA spleen delivery system Hopes for practical application to more effective vaccines
The research team of Dr. Satoshi Uchida (Professor, Tokyo Medical and Dental University), part of R&D Theme 2, has developed nanoparticles for delivering mRNA to the spleen in collaboration with the Innovation Center of NanoMedicine and several universities, demonstrating their efficacy. This system showed excellent vaccine effects in mice, and future applications in cancer immunotherapy are anticipated.
Conventional lipid-based nanoparticles tend to migrate to the liver and can cause side effects, while polymer nanoparticles are gaining attention as a method to overcome these issues. The research team developed a method to precisely control the PEG density on the surface of the nanoparticles by conjugating mRNA with PEG-modified RNA. Nanoparticles with appropriate PEG density were confirmed to efficiently deliver mRNA to spleen cells and be taken up by antigen-presenting cells.
Functional evaluation as a vaccine indicated that strong cellular immunity was induced, suggesting the potential to kill cancer cells. By encapsulating mRNA in nanoparticles, it can be protected from degradation and delivered to target organs. This research demonstrates the utility of a new mRNA delivery system using polymers, laying the foundation for the development of safe and effective vaccines in the future.
http://iyakutsushinsha.com/2024/03/06/mrnaの脾臓送達システム開発%E3%80%80より効果的なワクチ/
http://doi.org/10.1002/smsc.202300258
