Type Of Media：学術論文
Publication/Magazine/Media：Journal of Photopolymer Science and Technology
Author：Yukihiro Kanda, Hiroaki Takehara and Takanori Ichiki
Optical Oxygen Measurement using Microneedle of Bioabsorable Polymer
Microneedles made of polymer materials are attracting attention as minimally invasive medical devices for painless access to the body. To apply microneedles to in-body optical sensing, microneedles with a high aspect ratio (base diameter: 500 μm, height: 2 mm) containing platinum octaethylporphyrin, a phosphorescent probe for oxygen were fabricated using poly(l-lactic acid), a bioabsorbable polymer by vacuum-assisted micromolding process. The tip of the microneedle was excited with UV laser (wavelength: 375 nm), and the quenching time of the phosphorescence was measured by an avalanche photodiode and an oscilloscope at different oxygen partial pressures. The obtained phosphorescence lifetimes at the microneedle tip were approximately 100 μs and the relationship between phosphorescence lifetime and oxygen partial pressure was confirmed to follow the Stern-Volmer equation. This study suggests that microneedles could be applied as a minimally invasive in-body measurement tool by adding optical sensing capabilities to them.
http://doi.org/10.2494/photopolymer.36.15
