Type Of Media：学術論文
Publication/Magazine/Media：Journal of Photopolymer Science and Technology
Author：Masahiro Fukuhara, Hiroaki Takehara , Yukihiro Kanda, Akira Matsumoto and Takanori Ichiki
Functionalization of Poly-L-Lactic Acid Microneedle Tips using Hydrogel Photopolymerization
Although the diagnostic utility of interstitial fluid (ISF) has been extensively explored, collecting and sensing ISF in the body remains challenging. Microneedle devices offer a promising approach for minimally invasive methods to obtain ISF with a small volume or to sense biomolecules in the ISF within the body. In this study, we developed a microneedle with a small volume hydrogel block at the needle tip. The hydrogel block was formed through a photopolymerization reaction of polyethylene glycol diacrylate (PEGDA) under 365 nm irradiation. The hydrogel block measured 100 µm in diameter and 100 µm in length, with a total volume of 0.79 nL. The fabricated microneedle had a high-aspect ratio shape (500 µm in base diameter, 200 µm in top diameter, and 2000 µm in length), reaching the reticular layer containing blood vessels. Therefore, microneedle devices can be utilized to obtain ISF with a small volume and to sense biomolecules within the body.
http://doi.org/10.2494/photopolymer.37.233
