Type Of Media：学術論文
Publication/Magazine/Media：Journal of Controlled Release
Author：Yuto Honda, Haruna Haraguchi, Takeru Tsuda, Rui Ko, Kyohei Muguruma, Haochen Guo, Takahiro Nomoto, Yutaka Miura and Nobuhiro Nishiyama
Metal-phenolic network-based polymeric nanocarriers facilitating antibody cytoplasmic delivery and anti-tumor effects to orthotopic breast tumors
- Metal-phenolic network (MPN)-based nanocarrier enables systemic cytosolic antibody delivery.
- Neutral, PEG-coated MPN complex improves pharmacokinetics and tumor targeting.
- Antibodies effectively escape endosomes via MPN buffering effect.
- Enhanced antibody therapy observed in breast cancer mouse models.
- Non-cationic approach overcomes toxicity and stability limitations.
https://doi.org/10.1016/j.jconrel.2025.113929
