Type Of Media：全国紙
Publication/Magazine/Media：日本経済新聞
Facial bone regeneration with mRNA Tokyo Medical and Dental University, confirmed in rodents
Professor Keiji Iitaka, affiliated with R&D Theme 2, and his research group at Tokyo Medical and Dental University, have developed a new method for bone regeneration using messenger RNA (mRNA). This mRNA is designed to produce proteins that promote bone regeneration, specifically RANKS2, and proteins involved in angiogenesis, such as VEGF, within the body. In experiments, rats with holes in their jawbone were administered the polymer-coated mRNA once a week for three weeks, resulting in bone regeneration and a reduction in the size of the holes. No side effects were observed. This method presents a less burdensome alternative for treating bone defects caused by tumor resection or trauma compared to conventional treatments like artificial bone transplantation, with practical applications aimed for 4 to 5 years from now.
http://www.nikkei.com/article/DGXZQOUC278BJ0X20C23A6000000/
http://doi.org/10.1186/s41232-023-00285-3
